DMS Faculty Office: 4150

• Head, Large Animal Medicine Section
• BSN 1970, Georgetown University
• MS 1972, University of Pennsylvania
• VMD 1981, University of Pennsylvania
• PhD 1986, University of Georgia
• Diplomate, American College of Veterinary Internal Medicine

Pathophysiology and therapy of equine and bovine endotoxemia/septicemia. The primary research emphasis is in the physiological alterations induced by endotoxemia/septicemia in the bovine neonates. Of particular interest is potential therapeutic modalities including nonsteroidal and steroidal antiinflamatory agents, lazaroids, and oxygen radial modulators and glucose regulation during sepsis.

Large animal internal medicine; clinical nutrition; diagnostic and therapeutic techniques; physical examination.

Semrad, S.D., Rose, M.L., Adams, J.L. The effect of tirilazad mesylate (U74006F) on eicosanoid and tumor necrosis factor generation in healthy and endotoxemic neonatal calves. Circ. Shock, 40:235-242, 1993.

Semrad, S.D. Comparison of flunixin prednisolone, dimethyl sulfoxide, and a lazaroid (U74389F) for treating endotoxemic neonatal calves. Am. J. Vet. Res ., 54:1517-1522, 1993.

Semrad, S.D., and Dubielzig, R. Effect of repeated administration of Tirilazad Mesylate on healthy and endotoxemic calves: a pilot study. Can. J. Vet. Res., 58:67-70, 1994.

Gerros, T.C., Semrad, S.D., and Proctor, R.A. Effect of endotoxin dose on alterations in clinical, hematologic and metabolic variables in neonatal calves. Can. J. Vet. Res. , 59:34-39, 1995.