DSS Faculty Office: 4270B

• Associate Professor
• BVSc University of Bristol 1985
• MVetClinStud, The University of Sydney 1992
• PhD, University of Bristol 1990
• Membership of the Australian College of Veterinary Scientists in Small Animal Surgery 1992
• Membership of the American College of Veterinary Surgeons (Small Animal Surgery) 1995
• Membership of the European College of Veterinary Surgeons 1996
• Royal College of Veterinary Surgeons Registered Specialist in Small Animal Surgery 1996

Research interests are focused on skeletal adaptation to loading, stress (fatigue) fractures, long bone fracture repair, inflammatory stifle arthritis and associated degenerative cranial cruciate rupture in dogs. The Comparative Orthopaedic Research Laboratory has several major fields of interest, all applied to the musculoskeletal system. In bone adaptation, the rat ulna end-loading model is being used to examine the mechanisms that regulate functional adaptation of the skeleton. Currently, the laboratory is particularly interested in the neural control of functional adaptation and whether plasticity may exist in this regulatory system. Our laboratory is also focused on obtaining a fundamental understanding of the inflammatory stifle arthritis/cruciate rupture arthropathy in the dog. Currently, the laboratory is particularly interested in the mechanisms that lead to dysregulation of joint immune responses and the development of persistent stifle synovitis. Here, we expect to identify novel therapeutic targets for clinical trials.

Small Animal Orthopaedic Surgery

Small animal orthopaedic surgery, particularly fracture repair and treatment of dogs with cruciate rupture.

Edwards III RB, Lu Y, Bogdanske JJ, Muir P, Markel MD. Comparison of Mechanical Debridement and Radiofrequency Energy for Chondroplasty in an In Vivo Equine Model of Partial Thickness Cartilage Injury. Osteoarthr Cartil 2006, in press.

Muir P, Manley PA, Hao Z. COL-3 inhibition of collagen degradation in ruptured cranial cruciate ligament explants from dogs with stifle arthritis. Vet J 2006, in press.

Danielson KC, Fitzpatrick N, Muir P, Manley PA. Histomorphometry of fragmented medial coronoid process in the dog: A comparison of affected and normal coronoids. Vet Surg 2006, in press.

Loughrin E, Edwards RB, Hao Z, Muir P, Markel MD. A comparsion of techniques to determine chondrocyte viability after thermal injury. Am J Vet Res 2006, in press.

Muir P, Manley PA, Hao Z. Collagen degradation in ruptured canine cranial cruciate ligament. Vet J 2006;171:121-128.

Muir P, McCarthy J, Radtke CL, Markel MD, Santschi EM, Scollay MC, Kalscheur VL. Role of endochondral ossification of articular cartilage and adaptation of the subchondral plate in the development of fatigue microcracking of joints. Bone 2006;38:342-349.

Barrett JG, Hao Z, Graf BK, Heiner JP, Kaplan LD, Muir P. Inflammatory changes in ruptured canine and human anterior cruciate ligaments. Am J Vet Res 2005;66:2073-2080.

Muir P, Danova NA, Argyle DJ, Manley PA, Hao Z. Collagenolytic gene expression in cranial cruciate ligament and stifle synovial fluid in dogs with cranial cruciate ligament rupture. Vet Surg 2005;34:482-490.

Muir P, Schamberger GM, Manley PA, Hao Z. Localization of cathepsin K and tartrate-resistant acid phosphatase in synovial membrane and cranial cruciate ligament in dogs with cruciate disease. Vet Surg 2005;34:239-246.

Da Costa Gómez T, Barrett JG, Sample SJ, Radtke CL, Kalscheur VL, Lu Y, Santschi EM, Scollay MC, Markel MD, Muir P. Up-regulation of site-specific remodeling without accumulation of microcracking and loss of osteocytes. Bone 2005;37:16-24.

Colopy SA, Benz-Dean J, Barrett JG, Sample SJ, Lu Y, Danova NA, Kalscheur VL, Vanderby Jr. R, Markel MD, Muir P. Response of the osteocyte syncytium adjacent to and distant from microcracks during adaptation to cyclic fatigue loading. Bone 2004;35:881-891.

Dwyer KW, Provenzano PP, Muir P, Valhmu WB, Vanderby Jr. R. Blockade of the sympathetic nervous system degrades ligament in a rat MCL model. J Appl Physiol 2004;96:711-718.

Danova NA, Colopy SA, Radtke CL, Kalscheur VL, Markel MD, Vanderby Jr. R, McCabe RP, Escarcega AJ, Muir P. Degradation of bone structural properties by accumulation and coalescence of microcracks. Bone 2003;33:197-205.

Radtke CL, Danova NA, Scollay MC, Santschi EM, Da Costa Gomez T, Markel MD, Muir P. Fatigue fracture of the condyles of the third metacarpal/third metatarsal bone in Thoroughbred racehorses. Am J Vet Res 2003;64:1110-1116.

Hayashi K, Frank JD, Manley PA, Hao Z, Dubinsky C, Muir P. Histologic changes in ruptured canine cranial cruciate ligament. Vet Surg 2003;32:269-277.

Frank JD, Ryan M, Kalscheur VL, Ruaux-Mason CP, Muir P. Aging and accumulation of microdamage in canine bone. Bone 30:201-206, 2002.